Alprazolam mechanism of action encyclopedia
, like other benzodiazepines, acts through the GABA A receptor. was patented in 1971 and approved for medical use in the United States in 1981. is a Schedule IV controlled substance and is a common drug of abuse. It is available as a generic medication. U.S. Food and Drug Administration, Silver Spring, Maryland. 612,881 likes · 2,282 talking about this · 1,445 were here. The official page of the U.S. is a benzodiazepine . It affects chemicals in the brain that may be unbalanced in people with anxiety. is used to treat anxiety disorders, panic disorders, and anxiety caused by depression. . The exact of is unknown. Benzodiazepines bind to gamma aminobutyric acid receptors in the brain and enhance GABA-mediated synaptic inhibition; such actions may be responsible for the efficacy of in anxiety disorder and panic disorder. Pharmacokinetics Absorption : pharmacokinetics, clinical efficacy, and . Fawcett JA, Kravitz HM. , a triazolobenzodiazepine, is the first of this new class of benzodiazepine drugs to be marketed in the United States and Canada. It achieves peak serum levels in 0.7 to 2.1 hours and has a serum half-life of 12 to 15 hours. US Pharm. 2015;40:8-10. A vast amount of practice-related information is available to today’s healthcare practitioner. Specifically, pharmacists have access to drug information from a variety of resources, including print publications, subscription-based electronic databases , and In terms of the of benzodiazepines, their similarities are too great to separate them into individual categories such as anxiolytic or hypnotic. For example, a hypnotic administered in low doses produces anxiety-relieving effects, whereas a benzodiazepine marketed as an anti-anxiety drug at higher doses induces sleep. is extensively metabolized in humans, primarily by cytochrome P450 3A4 , to two major metabolites in the plasma: 4-hydroxyalprazolam and α-hydroxyalprazolam. A benzophenone derived from is also found in humans. Their half-lives appear to be similar to that of . The of benzodiazepines result is primarily from effects on the central nervous system. However, the benzodiazepines are not simply neuronal depressants, they have a complex pharmacological profile such that the clinical usefulness of individual drugs varies widely. Description , drug used in the treatment of anxiety disorders and panic disorder. is classified as a benzodiazepine and is marketed under the brand name Xanax by Pfizer, Inc. Learn more about in this article. Benzodiazepines and GABA receptors: an animation on their Gamma amino butyric acid is an inhibiting neurotransmitter that is present on human brains. As shown in the animation, gamma amino butyric acid promotes opening of a postsynaptic receptor, the GABA-A receptor. is an orally available benzodiazepine used predominantly for therapy of anxiety. As with most benzodiazepines, therapy has not been associated with serum aminotransferase or alkaline phosphatase elevations, buy cialis viagra levitra and clinically apparent liver injury from has been reported, but is very rare. is the most popular, comprehensive and up-to-date source of drug information online. Providing free, peer-reviewed, accurate and independent data on more than 24,000 prescription drugs, over-the-counter medicines natural products. Find patient medical information for Oral on including its uses, side effects and safety, interactions, pictures, warnings and user ratings. on GABA A receptors Claudia Campo-Soria , 1 Yongchang Chang , 2 and David S Weiss 3, * 1 Department of Neurobiology, UAB School of Medicine, 1719 Sixth Avenue South, CIRC410 Birmingham, AL 25394, U.S.A. binds with high affinity to glial cells. [14. . is a benzodiazepine that binds to a specific subunit on the GABA A receptor at a site that is distinct from the binding site of the endogenous GABA molecule. Adverse Events Occurring at an Incidence 1% or More Among Patients Treated with XANAX XR The prescriber should be aware that adverse event incidence cannot be used to predict the incidence adverse events in the course usual medical practice where patient characteristics and other factors differ from those which prevailed in the clinical trials. NIRAVAM™ contains which is a triazolo analog of the 1,4 benzodiazepine class of central nervous system-active compounds. NIRAVAM™ is an orally administered formulation of which rapidly disintegrates on the tongue and does not require water to aid dissolution or swallowing. has a fast onset and symptomatic relief. Ninety Diazepam percent of Action of peak effects are achieved within the first hour of using in preparation for panic disorder and full peak effects are achieved in 1.5 and 1.6 hours respectively. extended-release tablets are contraindicated in patients with known sensitivity to this drug or other benzodiazepines. extended-release may be used in alprazolam patients with open of action angle glaucoma who are receiving appropriate therapy, but is contraindicated in patients with acute narrow angle glaucoma.